REPARE THERAPEUTICS INC.

7171 Frederick-Banting, Building 2

Suite 270

St-Laurent, Québec H4S 1Z9

Canada

August 15, 2024

Via EDGAR

U.S. Securities and Exchange Commission

Division of Corporation Finance

100 F Street, N.E.

Washington, D.C. 20549

Registration Statement on Form S-3

File No. 333-281298

Ladies and Gentlemen:

In accordance with Rule 461 under the Securities Act of 1933, as amended, Repare Therapeutics Inc. (the “Registrant”) hereby requests that the U.S. Securities and Exchange Commission (the “Commission”) take appropriate action to cause the above-referenced Registration Statement on Form S-3 (File No. 333-281298) (the “Registration Statement”) to become effective at 4:00 p.m., Eastern Time, on Monday, August 19, 2024, or as soon as practicable thereafter, or at such later time as the Registrant may orally request via telephone call to the staff of the Commission (the “Staff”). The Registrant hereby authorizes Courtney T. Thorne of Cooley LLP, counsel to the Registrant, to make such request on its behalf.

Once the Registration Statement has been declared effective, please orally confirm that event with Courtney T. Thorne of Cooley LLP at (617) 937-2318, or, in her absence, Trey Reilly of Cooley LLP at (212) 479-6502.

Very truly yours,

Divakar Gupta, Cooley LLP

Courtney T. Thorne, Cooley LLP

Trey Reilly, Cooley LLP